Flavonoids in Kidney Health and Disease

Vargas, Félix; Romecín, Paola; Wangesteen, Rosemary; Atucha, Noemí M.; García-Estañ, Joaquín; García-Guillén, Ana I.; Vargas-Tendero, Pablo; Paredes, M. Dolores

Publication:
Flavonoids in Kidney Health and Disease

dc.contributor.author	Vargas, Félix
dc.contributor.author	Romecín, Paola
dc.contributor.author	Wangesteen, Rosemary
dc.contributor.author	Atucha, Noemí M.
dc.contributor.author	García-Estañ, Joaquín
dc.contributor.author	García-Guillén, Ana I.
dc.contributor.author	Vargas-Tendero, Pablo
dc.contributor.author	Paredes, M. Dolores
dc.contributor.department	Fisiología
dc.date.accessioned	2024-01-23T13:07:01Z
dc.date.available	2024-01-23T13:07:01Z
dc.date.issued	2018-04-24
dc.description	© 2018. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the published version of a published work that appeared in final form in Frontiers in Physiology	es
dc.description.abstract	This review summarizes the latest advances in knowledge on the effects of flavonoids on renal function in health and disease. Flavonoids have antihypertensive, antidiabetic, and antiinflammatory effects, among other therapeutic activities. Many of them also exert renoprotective actions that may be of interest in diseases such as glomerulonephritis, diabetic nephropathy, and chemically-induced kidney insufficiency. They affect several renal factors that promote diuresis and natriuresis, which may contribute to their well-known antihypertensive effect. Flavonoids prevent or attenuate the renal injury associated with arterial hypertension, both by decreasing blood pressure and by acting directly on the renal parenchyma. These outcomes derive from their interference with multiple signaling pathways known to produce renal injury and are independent of their blood pressure-lowering effects. Oral administration of flavonoids prevents or ameliorates adverse effects on the kidney of elevated fructose consumption, high fat diet, and types I and 2 diabetes. These compounds attenuate the hyperglycemia-disrupted renal endothelial barrier function, urinary microalbumin excretion, and glomerular hyperfiltration that results from a reduction of podocyte injury, a determinant factor for albuminuria in diabetic nephropathy. Several flavonoids have shown renal protective effects against many nephrotoxic agents that frequently cause acute kidney injury (AKI) or chronic kidney disease (CKD), such as LPS, gentamycin, alcohol, nicotine, lead or cadmium. Flavonoids also improve cisplatin- or methotrexate-induced renal damage, demonstrating important actions in chemotherapy, anticancer and renoprotective effects. A beneficial prophylactic effect of flavonoids has been also observed against AKI induced by surgical procedures such as ischemia/reperfusion (I/R) or cardiopulmonary bypass. In several murine models of CKD, impaired kidney function was significantly improved by the administration of flavonoids from different sources, alone or in combination with stem cells. In humans, cocoa flavanols were found to have vasculoprotective effects in patients on hemodialysis. Moreover, flavonoids develop antitumor activity against renal carcinoma cells with no toxic effects on normal cells, suggesting a potential therapeutic role in patients with renal carcinoma.	es
dc.format	application/pdf	es
dc.format.extent	12	es
dc.identifier.citation	Front. Physiol., 24 April 2018, Sec. Integrative Physiology, Volume 9 - 2018 \|
dc.identifier.doi	https://doi.org/10.3389/fphys.2018.00394
dc.identifier.issn	Electronic: 1664-042X
dc.identifier.uri	http://hdl.handle.net/10201/137600
dc.language	eng	es
dc.publisher	Frontiers	es
dc.relation	This study was supported by grants from the Carlos III Health Institute of Spain, and the Red de Investigación Renal REDinREN number 5 012/0021. FEDER una manera de hacer Europa.	es
dc.relation.publisherversion	https://www.frontiersin.org/articles/10.3389/fphys.2018.00394/full	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Flavonoides	es
dc.subject	Función Renal	es
dc.subject	Kidney function	es
dc.subject	Acute kidney injury	es
dc.subject	Chronic kidney disease	es
dc.subject	Flavonoids	es
dc.subject	Nephroprotection	es
dc.subject	Diabetes mellitus	es
dc.subject	Arterial hypertension	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina::612 - Fisiología	es
dc.title	Flavonoids in Kidney Health and Disease	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es