Publication: Microanatomy of lymphocyte-endothelial interactions
at the high endothelial venules of lymph nodes
Authors
Tohya, Kazuo ; Umemoto, Eiji ; Miyasaka, Masayuki
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Lymphocyte trafficking into lymph nodes
and Peyer’s patches is mediated primarily by specifically
differentiated venules, called high endothelial venules
(HEVs), located in the tissue parenchyma. HEVs have a
unique morphology and phenotype, which enables them
to interact with circulating lymphocytes efficiently. That
is, the HEV endothelial cells have a tall and plump
appearance, and constitutively express multiple adhesion
molecules and chemokines on their surface. These
molecules can interact with cognate receptors on
circulating lymphocytes, thereby mediating the stepwise
and sequential lymphocyte adhesion and transendothelial
migration (TEM) at the HEV endothelial luminal
surface. This review summarizes the fine morphological
aspects of the unique HEV endothelial cells, with special
reference to the spatial distribution of the adhesion
molecules and chemokines that regulate lymphocyte
migration.
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