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The triple role of glutathione S-transferases in mammalian male fertility

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dc.contributor.authorLlavanera, Marc
dc.contributor.authorMateo Otero, Yentel
dc.contributor.authorBonet, Sergi
dc.contributor.authorBarranco Cascales, Isabel
dc.contributor.authorFernández Fuerstes, Beatriz
dc.contributor.authorYeste, Marc
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2025-10-16T12:37:08Z
dc.date.available2025-10-16T12:37:08Z
dc.date.copyright© 2019, Springer Nature Switzerland AG
dc.date.issued2019-12-05
dc.description.abstractMale idiopathic infertility accounts for 15-25% of reproductive failure. One of the factors that has been linked to this condition is oxidative stress (OS), defined as the imbalance between antioxidants and reactive oxygen species. Amongst the different factors that protect the cell against OS, the members of the glutathione S-transferase (GST) superfamily play an important role. Interestingly, reduction or lack of some GSTs has been associated to infertility in men. Therefore, and to clarify the relationship between GSTs and male fertility, the aim of this work is to describe the role that GSTs play in the male reproductive tract and in sperm physiology. To that end, the present review provides a novel perspective on the triple role of GSTs (detoxification, regulation of cell signalling and fertilisation), and reports their localisation in sperm, seminal plasma and the male reproductive tract. Furthermore, we also tackle the existing correlation between some GST classes and male fertility. Due to the considerable impact of GSTs in human pathology and their tight relationship with fertility, future research should address the specific role of these proteins in male fertility, which could result in new approaches for the diagnosis and/or treatment of male infertility.
dc.formatapplication/pdf
dc.format.extent12
dc.identifier.citationCellular and Molecular Life Sciences, 2020, Vol. 77, pp. 2331–2342
dc.identifier.doihttps://doi.org/10.1007/s00018-019-03405-w
dc.identifier.eissn1420-9071
dc.identifier.issn1420-682X
dc.identifier.urihttp://hdl.handle.net/10201/167049
dc.languageeng
dc.relationThe authors acknowledge the support from the European Commission (H2020-MSCA-IF-79212); the Ministry of Science, Innovation and Universities, Spain (Grants RYC-2014-15581, AGL2016-81890-REDT, AGL2017-88329-R and FJCI-2017-31689); and Regional Government of Catalonia, Spain (2017-SGR-1229). The authors would also like to thank Servier Medical Art for their image bank used to create all figures.
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00018-019-03405-w
dc.rightsAttribution 4.0 International
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCell signaling
dc.subjectDetoxification
dc.subjectFertilisation
dc.subjectGSTs
dc.subjectInfertility
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleThe triple role of glutathione S-transferases in mammalian male fertility
dc.typeinfo:eu-repo/semantics/article
dcterms.publisherSpringer
dspace.entity.typePublicationes
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relation.isAuthorOfPublication3c34d0d5-7d7d-4bcc-a119-8906f53baa7b
relation.isAuthorOfPublication.latestForDiscovery3c34d0d5-7d7d-4bcc-a119-8906f53baa7b
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