Publication:
Tomato Juice Supplementation Influences the Gene Expression Related to Steatosis in Rats

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dc.contributor.authorPeriago Castón, María Jesús
dc.contributor.authorElvira Torales, Laura Inés
dc.contributor.authorNavarro González, Inmaculada
dc.contributor.authorGonzález Barrio, Rocío
dc.contributor.authorMartín-Pozuelo, Gala
dc.contributor.authorDomenech, Guillermo
dc.contributor.authorGarcía Alonso, Javier
dc.contributor.authorSeva Alcaraz, Juan
dc.contributor.departmentTecnología de Alimentos, Nutrición y Bromatología
dc.date.accessioned2024-01-29T12:08:41Z
dc.date.available2024-01-29T12:08:41Z
dc.date.created2018-08-03
dc.date.issued2018-09-02
dc.description© 2018. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the accepted version of a published work that appeared in final form in Nutrients.es
dc.description.abstractThe objective of this work was to identify the effect of tomato juice on the expression of genes and levels of metabolites related to steatosis in rats. Male Sprague Dawley rats (8 weeks-old) were grouped (6 rats/group) in four experimental groups: NA (normal diet and water), NL (normal diet and tomato juice), HA (high-fat diet and water), and HL (high-fat diet and tomato juice). After an intervention period of 5 weeks, rats were sacrificed and biochemical parameters, biomarkers of oxidative stress, liver metabolites, and gene expression were determined. Although the H diet provoked dislipemia related to steatosis, no changes in isoprostanes or liver malondialdehyde (MDA) were observed. Changes in the gene expression of the HA group were produced by the high consumption of fat, whereas the consumption of tomato juice had different effects, depending on the diet. In the NL group, the genes involved in -oxidation were upregulated, and in groups NL and HL upregulation of CD36 and downregulation of APOB and LPL were observed. In addition, in the HL group the accumulation of lycopene upregulated the genes FXR and HNF4A, which have been suggested as preventive factors in relation to steatosis. Regarding the metabolomics study, intake of tomato juice stimulated the biosynthesis of glutathione and amino acids of the transulfurization pathway, increasing the levels of metabolites related to the antioxidant response.es
dc.formatapplication/pdfes
dc.format.extent18es
dc.identifier.citationNutrients 2018, 10(9), 1215
dc.identifier.doihttps://doi.org/10.3390/nu10091215
dc.identifier.urihttp://hdl.handle.net/10201/137965
dc.languageenges
dc.publisherMDPIes
dc.relationProjectos MINECO (Spanish)/FEDER-EU BIO2012-38103 y CONSOLIDER Fun-C-Food CSD2007. Laura Inés Beca predoctoral de Elvira-Torales tSecretaria de Educación Pública del Gobierno de México (ITESTB-003 PRODEP).es
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/10/9/1215es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectLycopenees
dc.subjectNon-alcoholic fatty liver disease (NAFLD)es
dc.subjectOxidative biomarkerses
dc.subjectGene expressiones
dc.subjectQuantitative metabolomicses
dc.subject.otherCDU::6 - Ciencias aplicadases
dc.titleTomato Juice Supplementation Influences the Gene Expression Related to Steatosis in Ratses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationf4f4c0d0-67f8-43f4-afa3-7bf3d0f3c03a
relation.isAuthorOfPublication.latestForDiscoveryf4f4c0d0-67f8-43f4-afa3-7bf3d0f3c03a
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