Publication: Lipid signaling and cell responses at the nuclear level
Authors
Neri, L.M. ; Capitani, S. ; Borgatti, P. ; Martelli, A.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The nucleus is known to be a site for an
active lipid metabolism. Although phospholipids are
present in the nuclear envelope, evidence suggests that
they are also located further inside the nucleus. The
function of these intranuclear lipids has escaped
clarification for many years. Early experiments showed
that they can interact with DNA double helix affecting
its thermal stability and can influence RNA synthesis in
isolated nuclei. However, in the last 10 years several
investigations have suggested that they may be involved
in signal transduction pathways at the nuclear level and a
growing body of evidence supports this hypothesis
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