Publication: Development of the mouse mandibles and clavicles in the absence of skeletal myogenesis
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Date
2007
Authors
Rot-Nikcevic, I. ; Downing, K.J. ; Hall, B.K. ; Kablar, B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In this report we employed double-knock-out
mouse embryos and fetuses (designated as Myf5-/-:
MyoD-/- that completely lacked striated musculature to
study bone development in the absence of mechanical
stimuli from the musculature and to distinguish between
the effects that static loading and weight-bearing exhibit
on embryonic development of skeletal system. We
concentrated on development of the mandibles (=
dentary) and clavicles because their formation is
characterized by intramembranous and endochondral
ossification via formation of secondary cartilage that is
dependent on mechanical stimuli from the adjacent
musculature. We employed morphometry and
morphology at different embryonic stages and compared
bone development in double-mutant and control
embryos and fetuses. Our findings can be summarized as
follows: a) the examined mutant bones had significantly
altered shape and size that we described
morphometrically, b) the effects of muscle absence
varied depending on the bone (clavicles being more dependent than mandibles) and even within the same
bone (e.g., the mandible), and c) we further supported
the notion that, from the evolutionary point of view,
mammalian clavicles arise under different influences
from those that initiate the furcula (wishbone) in birds.
Together, our data show that the development of
secondary cartilage, and in turn the development of the
final shape and size of the bones, is strongly influenced
by mechanical cues from the skeletal musculature.
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