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The role of high cholesterol-high fructose diet on coronary arteriosclerosis

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dc.contributor.authorSwier, Vicki J.
dc.contributor.authorTang, Lin
dc.contributor.authorRadwan, Mohamed M.
dc.contributor.authorHunter III, William J.
dc.contributor.authorAgrawa, Devendra K.
dc.date.accessioned2021-04-13T06:33:09Z
dc.date.available2021-04-13T06:33:09Z
dc.date.issued2016
dc.description.abstractThe effect of fructose in conjunction with high cholesterol diet in the development of atherosclerotic lesions in coronary arteries is not well established. Microswine were fed high cholesterol (HC) or a high cholesterol-high fructose (HCHF) diet containing 18-20% calories from fructose. All swine had high levels of serum cholesterol and non-HDL, thickened intima and accumulation of collagen in the coronaries. Swine fed with HC diet had less stenosis in coronary arteries, lower serum levels of non-HDL, triglycerides, cholesterol, and blood glucose than HCHF group. Coronary lesions in the HC swine were not as progressed as in HCHF and showed low LDL-expressed lipid-laden foam cells. The M1/M2 macrophage phenotype in the HCHF swine differed with the progression of atherosclerosis, with higher density of M1-phenotype in HCHF swine. There was high expression of CCR7 (M1-phenotype) in more advanced lesions in the fibrous cap-like areas, whereas M2- macrophages were abundant in the foam-cell cores. These findings suggest that the addition of a fructose to high cholesterol diet accelerates atherosclerotic lesions in coronary arteries with an increase in M1-macrophages and the propensity to develop features of metabolic syndrome.es
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dc.format.extent10es
dc.identifier.citationHistology and Histopathology, vol.31, nÂş2, (2016)
dc.identifier.doi10.1470/HH-11-652
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/106342
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAtherosclerosises
dc.subjectCoronary plaqueses
dc.subjectFructose dietes
dc.subjectMacrophageses
dc.subjectMetabolic syndromees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleThe role of high cholesterol-high fructose diet on coronary arteriosclerosises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.31, nÂş2 (2016)