Publication: The role of high cholesterol-high fructose diet on coronary arteriosclerosis
Authors
Swier, Vicki J. ; Tang, Lin ; Radwan, Mohamed M. ; Hunter III, William J. ; Agrawa, Devendra K.
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
10.1470/HH-11-652
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info:eu-repo/semantics/article
Description
Abstract
The effect of fructose in conjunction with
high cholesterol diet in the development of
atherosclerotic lesions in coronary arteries is not well
established. Microswine were fed high cholesterol (HC)
or a high cholesterol-high fructose (HCHF) diet
containing 18-20% calories from fructose. All swine had
high levels of serum cholesterol and non-HDL,
thickened intima and accumulation of collagen in the
coronaries. Swine fed with HC diet had less stenosis in
coronary arteries, lower serum levels of non-HDL,
triglycerides, cholesterol, and blood glucose than HCHF
group. Coronary lesions in the HC swine were not as
progressed as in HCHF and showed low LDL-expressed
lipid-laden foam cells. The M1/M2 macrophage
phenotype in the HCHF swine differed with the
progression of atherosclerosis, with higher density of
M1-phenotype in HCHF swine. There was high
expression of CCR7 (M1-phenotype) in more advanced
lesions in the fibrous cap-like areas, whereas M2-
macrophages were abundant in the foam-cell cores.
These findings suggest that the addition of a fructose to
high cholesterol diet accelerates atherosclerotic lesions
in coronary arteries with an increase in M1-macrophages
and the propensity to develop features of metabolic
syndrome.
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Citation
Histology and Histopathology, vol.31, nÂş2, (2016)
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