Publication: The role of fetal breathing-like movements in lung organogenesis
Authors
Inanlou, M.R. ; Baguma-Nibasheka, M. ; Kablar, B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In this review the recent findings concerning
the role of fetal breathing-like movements (FBMs) on
lung organogenesis are discussed. We first review the
consequences that the lack of FBMs has on lung
organogenesis and then we discuss the possible
pathways that may be employed in this process.
Specifically, we review the data in support of the notion
that FBMs are required for the cell cycle kinetics
regulation (i.e., cell proliferation and cell death) via the
expression of growth factors, such as platelet derived
growth factors (PDGFs) and insulin growth factors
(IGFs), and thyroid transcription factor 1 (TTF-1).
Moreover, the role of FBMs on biochemical
differentiation of Clara cells, type I and type II
pneumocytes is reviewed. Interestingly, even though
type II pneumocytes are able to synthesize surfactantassociated
proteins (SPs), in the complete absence of
FBMs, they are unable to compile, store and release the
surfactant. Similarly, in spite of the expression of some
early differentiation markers, in the absence of FBMs,
type I pneumocytes are unable to flatten in order to
allow the gas exchange in the lung. In fact, we are
currently employing the cDNA microarray analysis in
search for the molecules that might be specific for the
lacking functions in pneumocytes.
Key words: Lung hypoplasia, Mouse embry
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