Publication: Airway and lung parenchyma morphology during the respiratory cycle
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Date
2007
Authors
Escolar Castellón, J.de D. ; Escolar, M.A. ; Blasco, J. ; Ros, L.H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Objective: Describe the morphological
changes that take place in the lung parenchyma and in
the airways during the respiratory cycle with a view to
establishing a relationship between them. Subjects:
Adult Wistar rats. Interventions: The lungs were fixed at
seven different points in the respiratory cycle: Inflation,
10 and 20 cm. transpulmonary pressure, total lung
capacity. Deflation, 20, 15, 10 and 0 cm transpulmonary
pressure. Measurements: The lungs were processed for
morphometric study and bronchial and parenchymal
variables, such as lung volume, number of alveoli,
anatomic dead space, bronchial lumen surface and
bronchial wall surface were quantified. The results were
compared by analysis of variance (ANOVA) or the
Kruskal-Wallis and Mann-Whitney’s U tests. Results:
The lung volume, the number of alveoli and the
anatomic dead space increased with the increase of the
transpulmonary pressure and decreased with the decrease of it, the obtained values in deflation being
higher than those in inflation (p<0.05). The bronchial
lumen and the bronchial wall surfaces generally showed
higher values in inflation than in deflation (p<0.05).
Conclusions: The anatomic dead space was altered as a
consequence of the variations in airway diameter and
length. Lung parenchyma tension may have been of
influence in the variations of the bronchial wall
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