Publication: EGF receptor signaling in prostate morphogenesis and tumorigenesis
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Date
1999
Authors
Kim, H.G. ; Kassis, J. ; Souto, J.C. ; Turner, T. ; Wells, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The growth and differentiation of the prostate
gland are largely dependent on extracellular signaling
factors. In addition to androgens, many polypeptide
growth factors function through autocrine or paracrine
networks. The paracrine interaction between stromal and
epithelial cells is critical for androgen regulation,
morphogenesis, epithelial cell proliferation, and
secretory differentiation. Efforts to identify the essential
growth factors and studies on their effects have been
prompted by the fact that prostate cells in culture need
substances other than androgens for proliferation. In this
context, transforming growth factor-a and epidermal
growth factor, among others, have been studied
extensively. Recent advances have suggested that these
EGF receptor (EGFR) ligands play roles not only during
glandular development but also during neoplastic
transformation and tumor progression. The cell
responses most relevant to the role of this receptor
signaling are both mitogenesis and cell motility. The aim
of the review is to provide an overview of current
knowledge about EGFR and its ligands in the
organogenesis and tumorigenesis of the prostate gland.
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