Publication: Axonal and transsynaptic (transneuronal)
spread of Herpesvirus simiae (B virus)
in experimentally infected mice
Authors
Gosztonyi, Georg ; Falke, Dietrich ; Ludwig, Hanns
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In order to study the pathogenesis of B
virus infection of the nervous system, newborn and
young mice were inoculated by four different routes:
1. Intramuscular (i.m.) in the forelimb; 2. 1.m. in the
hindlimb; 3. Subcutaneous (S.C.) in the abdominal
wall; 4. Intraperitoneal (i.p.).Spread of virus was
followed by immunohistochemical demonstration of
vira1 antigen in tissue sections of the peripheral and
central nervous system. Three distinct patterns
emerged: 1. After i.m. limb inoculations, virus
progressed along the ipsilateral dorsal column, the
bilateral spinothalamic and bilateral spinoreticular
systems and along central autonomic pathways.
2. After S.C. inoculation, the dorsal column was
spared, otherwise the spread was similar to that
following i.m. inoculations. 3. After i.p. inoculation,
virus spread in the spinal cord bilaterally, mainly along
spinothalamic and central autonomic pathways. The
peripheral motoneurons were conspicuously spared,
even in the i.m. inoculation mode. In the brain stem,
B virus antigen appeared bilaterally, at multiple sites.
In the cerebrum, virus infected cells appeared first in
the thalamus, hypothalamus and the motor cortex.
The mode of spread from spinal levels was mainly
orthograde along the ascending systems (dorsal
columns, spinothalamic, spinoreticular tracts), but also
retrograde along descending systems (pyramidal tract,
central autonomic pathways). Oligosynaptic systems
transmitted virus more quickly than the polysynaptic
ones. In the involvement of various neurona1 systems
in virus spread, a certain selectivity, sparing the
peripheral motoneuron and the cerebellar systems,
could be assessed.
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