Publication: Case report, esophageal collision tumor (oat cell carcinoma and adenocarcinoma)
in Barrett´s esophagus: immunohistochemical,
electron microscopy and LOH analysis
Authors
González, L.M. ; Sanz Esponera, J. ; Saez, C. ; Alvarez, T. ; Sierra, E. ; Sanz Ortega, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We report a case of an esophageal collision
tumor composed of adenocarcinoma and oat cell
carcinoma. Both tumors appeared to arise from
dysplastic Barrett's mucosae in a 75-year-old man.
Immunohistochemical stains and electron microscopy
demonstrated a separate identity for each of the tumors
in collision. Molecular analysis of microsatellite regions
was performed in different microdissected areas.
Identical loss of heterozygosity (LOH) at 9p21 and
17p13 was determined in the three different
microdissected areas of the adenocarcinoma component.
LOH was not determined in any area of the oat cell
carcinoma. This is the first study that analyzes the allele
status of an esophageal collision tumor. Our findings
suggest a biclonal origin for both components of the
collision tumor.
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