Publication: Presence and distribution of 5HT-, VIP-, NPY-, and SP-immunoreactive structures in adult mouse lung
Authors
Verastegui, C. ; Fernandez-Vivero, J. ; Prada, A. ; Rodríguez, F. ; Romero, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A large number of biologically active
substances have been identified and characterised in the
respiratory tract of severa1 mammals. These substances
(amines and peptides) exert important regulatory
influences on respiratory functions, and they act as
neurotransmitters/neuromodulators, both being released
from nerve terminals as neuroendocrine cells. However,
these substances can also have other effects which
suggest a paracrine action. Thus, to understand the role
of amines and peptides in the lung, it is important to
explore their localisation in different species. By using
immunocytochemical staining methods we have studied
the morphology and distribution of serotonin-, Substance
P-, neuropeptide Y- and VIP-like immunoreactivity in
the adult mouse lung. Moreover a pretreatment with
colchicine, pargyline and 5-hydroxytryptophan as
staining enlargement method was made. A widespread
distribution of isolated endocrine cells and neuroepithelial
bodies containing 5HT-like immunoreactivity
was recorded within the lung. NPY-like immunoreactive
nerve fibres were localised in the airway smooth muscle
and surrounding the blood vessels. VIP-like
immunoreactivity was revealed in single cells as well as
in some nerve fibres and ganglia around the blood
vessels and in the bronchial smooth muscle. SP-like IR
was observed in nerve fibres located in the smooth muscle of the airways, surrounding bronchi and
bronchioli but not next to the intrapulmonary blood
vessels. Their localisation both in cells and nerve fibres
of the respiratory system suggests that they play a role in
the regulatory function of the mouse respiratory tract,
exerting their influence by endocrine, paracrine,
neurosecretory pathways or a combination of al1 of
these.
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