Publication: High endothelial venules and cell adhesion molecules in B-cell chronic lymphocytic leukaemia and related low grade B-cell lymphoma leu kaemia II...
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Date
1994
Authors
Csanaky, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The expression of cell adhesion molecules
(LECAM-1, LFA-1, VLA-4, ICAM-1 and CD44)
of lymph nodes from B-cell chronic lymphocytic
leukaemia (B-CLL; mature: 16 cases, immature:
8), lymphocytic lymphoma (LL; M:5, IM:2) and
reactive lymph nodes (10) were investigated in
frozen tissue sections. In order to assess the B- and
T-cell compartments of the lymph nodes some
additional markers CD3, CD20, CD45 RO were
used, and for follicular dendritic reticulum cells (FDCs)
CD35. The expression of the LECAM-1 molecule
was correlated to the expression of activation
(CD23, CD25) and proliferation (Ki67) markers.
Findings, in accordance with the relevant data of
the literature, indicate that B-CLL and LL show
and identical adhesion profile to the mantle zone of
the germitial centres of reactive lymph nodes; narnely,
they were CD44+/LECAM- I+/VLA-4+. The T-zones
of the reactive lymph nodes were characterized
by an LFA-lf and the follicles by an ICAM-I+
pattern. while in B-CLL and LL cases the LFA-I+ and
ICAM- I + were detected without coexpression of
these molecules in only a small ii~imber of cases. The
ratio and location of CD3+ and LFA-I+ cells was very
similar in lyinph nodes from B-CLL and LL, and
from this fact may arise the suspicion that LFA-I+
reported in LL cases derive from the sometimes
significant T-cell compartment of the diseased lyrnph
nodes. The LECAM-I molecule did not show any
correlation with the investigated activation/proliferation
markers.
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