Publication: Electron microscopic study of sprouting dendrites in the ciliary ganglia of cat and monkey (Macaca fascicularís) following pre- and post-ganglionic axotomy
Loading...
Date
1997
Authors
Zhang, Y.L. ; Tan, C.K. ; Wong, W. C.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The present paper reports the ultrastructure
of dendritic sprouting and formation of associated
synapses in the ciliary ganglion of cat and monkey
induced by pre- and post-ganglionic axotomy. In both
series of experiments, sprouting dendrites were observed
mostly at 3-5 days postoperatively; such profiles were
identified by their dense packing of mitochondria and
glycogen-like granules. In longitudinal section, such
profiles appeared as expanded extensions from the
normal-looking dendritic trunks. None were observed to
arise directly from the neuronal soma. After
preganglionic nerve section, the cross-sectional
diameters of such profiles measured 2.211 .O pm (range:
0.9-6.2 pm) in cat and 2.4I0.7 y m (range: 0.9-5.5 pm)
in monkey. After postganglionic nerve section, the crosssectional
diameters of such profiles measured 2.110.7
pm (range: 0.8-4.5 pm) in cat and 2.811.4 pm (range:
1.1-7 .O p m) in monkey. After preganglionic axotomy, in
both cat and monkey, the axon terminals began to
degenerate at 3 days postoperatively and disappeared by
5 days postoperatively. However, at later postoperative
survival periods, the axon terminals reappeared and were
observed to make synaptic contacts with the sprouting
dendrites. Some of the sprouting dendrites were observed to degenerate, some as early as 3 days
postoperatively; such profiles did not appear to have any
synapse on them. After postganglionic axotomy, such
sprouting dendritic profiles were also observed to make
synaptic contacts with axon terminals; some were only
closely associated with profiles filled with synaptic
vesicles. The results thus suggest that through the
formation of new synapses, sprouting of dendrites
may have a role to play in neuronal survival after
axotomy.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.