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The effect of habitual sleep duration on weight loss during a behavioral weight loss intervention in a Mediterranean population

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Date
2025-09-19
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Authors
Rodríguez Martín, María ; Szczerbinski, Lukasz ; Garaulet Aza, Marta ; Dashti, Hassan S.
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Facultades de la UMU::Facultad de Biología
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Publisher
Elsevier
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Fisiología
DOI
https://doi.org/10.1016/j.tjnut.2025.09.010
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Abstract
Background Sleep duration affects metabolic health and regulates appetite, but its role in behavioral weight loss interventions remains unclear as prior studies are limited by small sample sizes, cross-sectional designs, and inconsistent findings. Objectives This study aims to examine the associations between nighttime sleep duration and weight loss during a behavioral intervention in adults with overweight or obesity in Spain. Methods This secondary analysis included adults with overweight or obesity from the Obesity, Nutrigenetics, Timing, and Mediterranean study, a 25-wk behavioral weight loss program. Participants self-reported sleep duration at enrollment and were categorized as short (<7 h), recommended (7–8 h), or long (>8 h) sleepers. Outcomes included percentage of weight loss, clinically meaningful or successful weight loss (≥5% of initial body weight), rate of weight loss (high/rapid rate ≥0.53 kg/wk), and attrition. Associations were examined using logistic regression and linear mixed-effects models adjusted for age, sex, baseline weight, intervention duration, and clinic site. Results Among 3628 participants (mean age 41.2 ± 14.1 y; 77.6% women), 23.7% reported sleeping >8 h, 60.9% reported sleeping 7–8 h, and 15.4% reported sleeping <7 h per night. Long sleepers had significantly lower average weight loss (7.42% of baseline weight) compared with recommended sleepers (7.90%, P = 0.015). Long sleep was associated with 21% lower odds of achieving a weight loss ≥5% of baseline weight [odds ratio (OR): 0.79; 95% confidence interval (CI): 0.66, 0.96], 25% lower odds of rapid weight loss (OR: 0.75; 95% CI: 0.63, 0.89), and 21% higher odds of attrition (OR: 1.21; 95% CI: 1.03, 1.43) compared with recommended sleep. No significant associations were observed for short sleepers. Linear mixed-effects models indicated lower weight loss among long sleepers [β: 0.099; standard error (SE): 0.040; P = 0.015], but not for short sleepers (β: −0.031; SE: 0.048; P = 0.514). Conclusions Habitual long sleep duration is associated with reduced weight loss success and increased risk of attrition in a behavioral weight loss intervention. This trial was registered at clinicaltrials.gov as NCT02829619.
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Weight loss , Obesity , Behavioral intervention , Long sleep , Attrition , Sleep duration
Citation
The Journal of Nutrition, Volume 155, Issue 11, November 2025, Pages 4060-4064
URI
http://hdl.handle.net/10201/236661
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