Publication: Age-related changes of the ultrastructure in the cardiomyopathic
hamster (UM-X7.1 Syrian hamster) parathyroid gland
Authors
Utsumi, M. ; Moriguchi, K. ; Takahashi, H. ; Kinoshita, C. ; Togari, A. ; Mizutani, M. ; Ohno, N.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We qualitatively and quantitatively
investigated parathyroid glands of the UM-X7.1
cardiomyopathic hamster at 1, 2, 6 and 12 months of age
to compare them with those of the normal hamster. We
found that at 1 month of age in the UM-X7.1 hamster,
the Golgi apparatus, lipid droplets and secretory granules
decreased. There were no significant differences
between the UM-X7.1 hamster and the control hamster
at 2 months of age. At 6 months of age, the Golgi
apparatus, rER and the secretory granules significantly
increased in the UM-X7.1 hamster. At 12 months of age,
the Golgi apparatus and lysosomes increased, while the
secretory granules decreased. Ultrastructurally, we
consider that in the UM-X7.1 hamster, the synthesis and
release of the parathyroid at 6 months of age may be
activated by an excessive amount of circulating
catecholamine, and the functional activity of the
parathyroid glands at 12 months of age may be
depressed by the increased plasma calcium level. These
findings suggest that the activities of the synthesis and
release of the parathyroid hormone were the highest at 6
months of age in the UM-X7.1 hamster.
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