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DNA-Ploidy, morphometric-stereological and P-Glycoprotein study of superficial bladder carcinomas

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1992_EUR UROL_DNA-Plidy, Morphometric-Stereological and P-Glycoprotein Study of Superficial Bladder Carcinomas.pdf(2.4 MB)
Date
1992
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Authors
Sánchez Fernández de Sevilla, M. C. ; Gil Salom, M. ; Pérez Bacete, M. ; Morell Cuadreny, L. ; Martínez Díaz, F. ; Iborra Juan, I. ; Fenollosa Entrena, B. ; Llombart Bosch, A.
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Publisher
S. Karger AG
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Oftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
DOI
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info:eu-repo/semantics/article
Description
© 1992 S. Karger AG. This document is the Published version of a Published Work that appeared in final form in European Urology.
Abstract
We carried out a DNA-ploidy, morphometri􀀜stereolcgic and P-glycoprotein study on 40 newly diagnosed superficial bladder cancer patients (G l-G2), cor­relating the results with histological grade and clinical outcome. Variations in the number of patients who present recurrences, progression or remain tumor-free during the whole follow-up period (at least 5 years) were not signif­icant when related to nuclear size, proliferative diploid index, presl!nce of aneuploidy and expression of P-glycoprotein. lt is striking how the majority of disease-free subjects showed a proliferative diploid index higher than 10%. Moreoyer .. 3 of them presented a11 aneuploid cell population. In our study, only histological grade showed a significant discriminatory level in terms of progression versus no progression in patients with superficial bladder cancer.
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Bladder cancer , DNA , Morphometry , Stereology , P-glycoprotein
Citation
European Urology, 1992, Vol. 21 (Suppl. J), pp. 16-21
URI
http://hdl.handle.net/10201/146306
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