Publication: Dynamin-related protein 1 (Drp1) mediating mitophagy contributes to the pathophysiology of nervous system diseases and brain injury
Authors
Wu, Qiong ; Luo, Cheng Liang ; Tao, Lu Yang
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-841
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info:eu-repo/semantics/article
Description
Abstract
As the main source of energy (celluar ATP)
in eukaryotic cells, mitochondria are involved in cellular
physiology and pathology. The balance of mitochondrial
dynamic, fission and fusion regulated by quality control
mechanisms, provides a guarantee for maintaining
mitochondrial function, even celluar function. Worn out
mitochondria would be removed through mitophagy
which is regulated by autophagy related proteins and
mitochondrial membrane proteins. Drp1, dynamicrelated protein 1, is regarded as one of the most
important proteins to evaluate mitochondrial fission
mediating mitophagy in neurodegenerative diseases (eg.
Alzheimer’s, Parkinson’s, Huntington’s, amyotrophic
lateral sclerosis) and heart failure. Recent studies have
focused on the roles of Drp1 in ischemia-induced
mitophagy in the hippocampal CA3 region, and
traumatic brain injury (TBI)-induced cell death together
with functional deficits. However, the exact mechanisms
have not been well characterized. In this review, we will
discuss and clarify the role of Drp1 and mitophagy in
nervous system diseases and brain injury therein, with a
special emphasis on their molecular mechanisms
mediating mitochondrial dynamics and mitophagy
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Citation
Histology and Histopathology, Vol.32, nº6, (2017)
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