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Membrane vesicles for nanoencapsulated sulforaphane increased their anti-inflammatory role on an In vitro human macrophage model.

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dc.contributor.authorYepes Molina, Lucía
dc.contributor.authorPérez Jiménez, María Isabel
dc.contributor.authorMartínez Esparza, M.
dc.contributor.authorTeruel, José A.
dc.contributor.authorRuiz Alcaraz, Antonio J.
dc.contributor.authorGarcía Peñarrubia, Pilar
dc.contributor.authorCarvajal, Micaela
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.date.accessioned2024-06-26T11:47:59Z
dc.date.available2024-06-26T11:47:59Z
dc.date.issued2022-02-09
dc.description© 2022 by the author. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published version of a Published Work that appeared in final form in International Journal of Molecular Sciences. To access the final edited and published work see https://doi.org/10.3390/ijms23041940es
dc.description.abstractAt present, there is a growing interest in finding new non‐toxic anti‐inflammatory drugs to treat inflammation, which is a key pathology in the development of several diseases with considerable mortality. Sulforaphane (SFN), a bioactive compound derived from Brassica plants, was shown to be promising due to its anti‐inflammatory properties and great potential, though its actual clinical use is limited due to its poor stability and bioavailability. In this sense, the use of nanocarriers could solve stability‐related problems. In the current study, sulforaphane loaded into membrane vesicles derived from broccoli plants was studied to determine the anti‐inflammatory potential in a human‐macrophage‐like in vitro cell model under both normal and inflammatory conditions. On the one hand, the release of SFN from membrane vesicles was modeled in vitro, and two release phases were stabilized, one faster and the other slower due to the interaction between SFN and membrane proteins, such as aquaporins. Furthermore, the anti‐inflammatory action of sulforaphane‐loaded membrane vesicles was demonstrated, as a decrease in interleukins crucial for the development of inflammation, such as TNF‐α, IL‐1β and IL‐6, was observed. Furthermore, these results also showed that membrane vesicles by themselves had anti‐inflammatory properties, opening the possibility of new lines of research to study these vesicles, not only as carriers but also as active compounds.es
dc.formatapplication/pdfes
dc.format.extent21es
dc.identifier.citationInternational Journal of Molecular Sciences, 2022, Vol. 23 (4): 1940
dc.identifier.doihttps://doi.org/10.3390/ijms23041940
dc.identifier.issnPrint: 1661-6596
dc.identifier.issnElectronic: 1422-0067
dc.identifier.urihttp://hdl.handle.net/10201/142690
dc.languageenges
dc.publisherMDPIes
dc.relationThis research was funded by the Spanish Ministry of Science and Innovation (AGL2016-80247-C2-1-R) and by CDTI (Spain) in collaboration with Peyfi, S.A, with a grant for L. Yepes-Molina (FPU17/02261).es
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/23/4/1940es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBroccolies
dc.subjectInflammationes
dc.subjectMacrophagees
dc.subjectMembrane vesicleses
dc.subjectNanocarrieres
dc.subjectSulforaphanees
dc.titleMembrane vesicles for nanoencapsulated sulforaphane increased their anti-inflammatory role on an In vitro human macrophage model.es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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