Publication:
Immunostaining of proinflammatory cytokines in renal cortex and medulla of rats exposed to gold nanoparticles

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dc.contributor.authorKhan, Haseeb A.
dc.contributor.authorIbrahim, Khalid E.
dc.contributor.authorKhan, Ayaat
dc.contributor.authorAlrokayan, Salman H.
dc.contributor.authorAlhomida, Abdullah S.
dc.date.accessioned2022-02-23T11:46:30Z
dc.date.available2022-02-23T11:46:30Z
dc.date.issued2017
dc.description.abstractRecently, gold nanoparticles (GNPs) have shown promising applications in targeted drug delivery and contrast imaging. Although in vitro cytotoxicity of GNPs has been thoroughly studied, there are limited data on in vivo toxicity of GNPs. In this study, we evaluated the effects of intraperitoneally injected 10 nm and 50 nm GNPs (5 µg/animal) on the expression of proinflammatory cytokines (IL-1β, IL-6 and TNF-α) on day 1 and day 5, post-exposure. The results of immunohistochemistry showed that both 10 nm and 50 nm GNPs induced an acute phase expression of proinflammatory cytokines in renal cortex and medulla. This proinflammatory response was comparatively more intense in renal medulla than cortex. All the three cytokines were undetectable in control cortex and medulla. In conclusion, both 10 nm and 50 nm GNPs caused an acute phase induction of proinflammatory cytokines in cortex and medulla of rat kidneys. An intense immunostaining of proinflammatory cytokines in renal medulla warrants further studies to evaluate the nephrotoxicity of GNPs to validate the safe application of GNPs for contrast imaging in renal insufficiency.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationHistology and Histopathology, Vol.32, nº6, (2017)
dc.identifier.doiDOI: 10.14670/HH-11-825
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/117306
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGold nanoparticleses
dc.subjectProinflammatory cytokineses
dc.subjectImmunohistochemistryes
dc.subjectKidneyes
dc.subjectRatses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleImmunostaining of proinflammatory cytokines in renal cortex and medulla of rats exposed to gold nanoparticleses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.32, nº6 (2017)