Publication: CD26: An expanding role in immune regulation and cancer
Authors
Dang, N.H. ; Morimoto, C.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
In this review, we highlight major aspects of
the biology of CD26, a dipeptidyl peptidase IV
(DPPIV)-containing surface glycoprotein with multiple
functions. In particular, we discuss findings
demonstrating that CD26/DPPIV has an essential role in
immune regulation as a T cell activation molecule and a
regulator of chemokine function. We also review recent
studies that identify key cellular molecules that
physically associate with CD26 and the potential
consequences of their interaction, including those with
clinically-related implications. Furthermore, we present
work suggesting a role for CD26 in the pathogenesis and
behavior of selected human cancers, both solid tumors
and hematological malignancies. We present recent
studies that investigate the potential role of CD26 as a
molecular target for novel treatment modalities for T cell
lymphoid malignancies and possibly other hematological
malignancies, with work involving the use of anti-CD26
monoclonal antibody, CD26-transfected cells as well as
soluble CD26 molecules.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.