Publication:
The regulatory role of HIF-1 in tubular epithelial cells in response to kidney injury

Thumbnail Image
Files
Qiu-35-321-330-2020.pdf(192.6 KB)
Date
2020
relationships.isAuthorOfPublication
relationships.isSecondaryAuthorOf
relationships.isDirectorOf
Authors
Qiu, Yumei ; Huang, Xiaowen ; He, Weichun
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-18-182
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The high sensitivity to changes in oxygen tension makes kidney vulnerable to hypoxia. Both acute kidney injury and chronic kidney disease are almost always accompanied by hypoxia. Tubular epithelial cells (TECs), the dominant intrinsic cells in kidney tissue, are believed to be not only a victim in the pathological process of various kidney diseases, but also a major contributor to kidney damage. Hypoxia inducible factor- 1 (HIF-1) is the main regulator of adaptive response of cells to hypoxia. Under various clinical and experimental kidney disease conditions, HIF-1 plays a pivotal role in modulating multiple cellular processes in TECs, including apoptosis, autophagy, inflammation, metabolic pattern alteration, and cell cycle arrest. A comprehensive understanding of the mechanisms by which HIF-1 regulates these cellular processes in TECs may help identify potential therapeutic targets to improve the outcome of acute kidney injury and delay the progression of chronic kidney disease.
publication.page.subject
Kidney , Hypoxia inducible factor-1 , Tubular epithelial cell , Apoptosis , Autophagy , Inflammation , Metabolic pattern alteration , Cell cycle arrest
Citation
Histology and Histopathology Vol. 35, nĀŗ4 (2020)
URI
http://hdl.handle.net/10201/125568
item.page.embargo
Collections
Histology and histopathology Vol.35, nĀŗ4 (2020)
Ir a EstadĆ­sticas