Publication: Structure and function of melanocytes, Microscopic
Authors
Hirobe, T.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Melanocytes characterized by their
tyrosinase activity, melanosomes and dendrites locate
in the basa1 layer of epidermis and hair bulb in the
skin of mice. Melanocytes differentiate from undifferentiated
melanoblasts derived from embryonic
neural crest. Melanocyte-stimulating hormone plays
an important role in the regulation of the differentiation
of mouse melanocytes in the epidermis and hair bulb by
inducing tyrosinase activity, melanosome formation,
transfer of melanosomes and increased dendritogenesis.
The proliferative activity of differentiating
epidermal melanocytes of newborn mice during the
healing of skin wounds is regulated by semidominant
genes, suggesting that the genes are involved in
regulating the proliferative activity of epidermal
melanocytes during differentiation. The morphology and
differentiated functions of mouse melanocytes are
shown to be influenced by environmental factors
such as ultraviolet and ionizing radiations. From
the results of serum-free culture of mouse epidermal
melanoblasts, basic fibroblast growth factor is shown
to stimulate the sustained proliferation of melanoblasts
in the presence of dibutyryl adenosine 3 ' 3 -
cyclic monophosphate and keratinocytes. In contrast,
melanocyte differentiation in serum-free culture
is induced by melanocyte-stimulating hormone
in the presence of keratinocytes. These results
suggest that the structure and function of mouse
melanocytes in the epidermis and hair bulb are
controlled by both genetic factors and local
tissue environment, such as hormones and growth
factors.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.