Publication: Sex‑dependent effects of forced exercise in the body composition of adolescent rats
Authors
Kutsenko Shchegolska, Yevheniy ; Barreda, A. ; Toval Sánchez, José Ángel ; Garrigos, D. ; Martínez Morga, Marta ; Ribeiro do Couto, Bruno ; Ferrán Bertone, José Luis
item.page.secondaryauthor
Facultad de Medicina
item.page.director
Publisher
Nature Research
publication.page.editor
publication.page.department
DOI
https://doi.org/10.1038/s41598-021-89584-8
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Determining the body composition during adolescence can predict diseases such as obesity, diabetes, and metabolic syndromes later in life; and physical activity became an effective way to restore changes in body composition. However, current available literature assessing the body composition before, during and after adolescence in female and male rodents by in vivo techniques is scarce. Thus, by using computerized tomography, we aimed to define the baseline of the weight and body composition during the adolescence and young adulthood of female and male Sprague–Dawley rats (on P30, P60 and P90) under standard diet. Then, we determined the effect of 18 days of forced exercise on the body weight and composition during the early adolescence (P27-45). The highest percentual increments in weight, body volume and relative adipose contents occurred during the female and male adolescence. Forced running during the early adolescence decreased weight, body volume and relative adipose delta and increment values in males only. The adolescence of rats is a period of drastic body composition changes, where exercise interventions have sex-dependent effects. These results support a model that could open new research windows in the field of adolescent obesity.
publication.page.subject
Citation
Sci Rep 11, 10154 (2021)
item.page.embargo
Collections
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by/4.0/