Publication: Nuclear vlimata and aneuploidy in embryonic cells is caused by meiosis. Behaviour and properties of meiotic cells
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Date
1995
Authors
Logothetou-Rella, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This study demonstrates that human
embryonic cells divide by meiosis. The use of
trophoblastic tissue cells (early embryo) and amniotic
cells (late embryo) exhibited the following characteristic
events of meiosis: nuclear (NVs) and nucleolar (NuVs)
vlimata formation; NV invasion in host cells; extrusion
of chromosomes; nuclear fusion; metaphase fusion;
hybrid cell formation; nuclear, nucleolar and
cytoplasmic bridges, chromosomal transfer, variablesized
nuclei; nuclear fragmentation; condensed meiotic
chromosomes; "0" chromosome; and aneuploidy. Two
types of nuclear bridges (NBs) were identified and
defined as communicative tubules through which
chromosomal transfer among cells is achieved. The wall
of NBs is an extension of the nuclear membrane and the
lumen contained chromosomal fusion substance (CFS).
Embryonic cells formed glycosaminoglycan-sacs (GSGsacs)
and rivulets, forming a cytoplasmic communicative
system. The extracellular matrix (ECM), GSG-sacs and
CFS were composed of glycosaminoglycan-bound
protease. The protease which immuno-crossreacted with
the al-chymotrypsin antiserum was the meiotic calciumactivated
neutral proteinase (CANP). Cytogenetic
analysis of early embryonic cells showed higher ratio of
aneup1oidy:diploidy than late embryonic cells. The results are discussed in terms of differentiation-mitosis
and undifferentiation-meiosis. These observations lead
to an embryonic cell life cycle identical to that of
malignant cells as follows:
meiosis invasion
Zygote & NVs and NuVs - recipient host
nuclear fusion
cells - hybrid cells-w organogenesis
metaphase fusion
+ mitosis
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