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Decreased survival in patients with pancreatic cancer may be associated with an increase in histopathological expression of inflammasome marker NLRP3

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dc.contributor.authorFraile Martínez, Oscar
dc.contributor.authorGarcía Montero, Cielo
dc.contributor.authorPekarek, Leonel
dc.contributor.authorSaz, Jose V.
dc.contributor.authorÁlvarez Mon, Miguel Ángel
dc.contributor.authorBarrena Blázquez, Silvestra
dc.contributor.authorGarcía Honduvilla, Natalio
dc.contributor.authorBuján, Julia
dc.contributor.authorAsúnsolo, Ángel
dc.contributor.authorCoca, Santiago
dc.contributor.authorÁlvarez Mon, Melchor
dc.contributor.authorGuijarro, Luis G.
dc.contributor.authorSaez, Miguel A.
dc.contributor.authorOrtega, Miguel A.
dc.date.accessioned2023-12-05T09:10:19Z
dc.date.available2023-12-05T09:10:19Z
dc.date.issued2024
dc.description.abstractPancreatic cancer is a malignant neoplasm that, despite its low frequency, has a 5-year survival rate of less than 10%. The study of different histopathological markers has allowed a better understanding of the onset and development of this type of tumor as well as facilitating an approach to clinical variables based on their diagnostic, prognostic, and predictive value. In this sense, the NLRP3 protein of the inflammasome has been shown to be a component of great relevance in the initiation and progression of pancreatic cancer, although the value of this biomarker in patients has not yet been clarified. In this study, we selected 41 patients with pancreatic cancer and followed them for 60 months (5 years), evaluating their NLRP3 expression using immunohistochemical techniques. Furthermore, by performing Kaplan-Meier curves, we evaluated the survival of these patients in relation to their NLRP3 expression. Our results show that a significant percentage of our cohort had high expression of this component (90.74%) and that there is an inverse relationship between the expression of NLRP3 and patient survival. High levels of NLRP3 expression are related to lower survival and worse prognosis in these patients, possibly due to an ineffective immune system response and increased tumor-promoted inflammation. Future studies should be aimed at confirming these results in larger groups and evaluating various clinical strategies based on this knowledge.es
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dc.format.extent6es
dc.identifier.citationHistology and Histopathology Vol. 39, nº1 (2024)
dc.identifier.doihttps://doi.org/10.14670/HH-18-617
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/136405
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPancreatic canceres
dc.subjectInflammasomees
dc.subjectNLRP3es
dc.subjectPrognostic biomarkeres
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleDecreased survival in patients with pancreatic cancer may be associated with an increase in histopathological expression of inflammasome marker NLRP3es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.39, nº1 (2024)