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Usefulness of identifying G-protein-coupled receptor dimers for diagnosis and therapy of neurodegenerative diseases and of gliomas

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dc.contributor.authorReyes Resina, Irene
dc.contributor.authorAguinaga, David
dc.contributor.authorLabandeira García, José Luis
dc.contributor.authorLanciego, José Luis
dc.contributor.authorNavarro, Gemma
dc.contributor.authorFranco, Rafael
dc.date.accessioned2022-05-18T12:04:47Z
dc.date.available2022-05-18T12:04:47Z
dc.date.issued2018
dc.description.abstracty. Immunochemical detection of G-proteincoupled receptors (GPCRs) in cells and tissues was a technical challenge for years. After the discovery of formation of GPCR dimers/trimers/tetramers in transfected cells, a most recent challenge has been to confirm receptor-receptor interactions in natural sources. The occurrence of dimers or higher order oligomers is important from a therapeutic point of view, mainly because their physiology/pharmacology is different from those of individual receptors. On the one hand, pathophysiological factors need to count more on GPCR dimers than on individual receptors. On the other hand, the expression of dimers, trimers, etc. may change in pathological conditions and/or along the course of a disease. This review will focus on G-protein-coupled receptor dimers, on how to detect them by novel histological techniques and on how the detection may be used in diagnosis and therapy of ailments of the central nervous system, for instance in neurodegenerative diseases and gliomas.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistology and Histopathology, Vol.33, nº9, (2018)
dc.identifier.doiDOI: 10.14670/HH-11-963
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/120191
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCB1es
dc.subjectCB2es
dc.subjectCannabinoid receptores
dc.subjectGPR55es
dc.subjectAdenosine receptores
dc.subjectDopamine receptores
dc.subjectD1es
dc.subjectD2es
dc.subjectD3es
dc.subjectHeteroreceptor complexes
dc.subjectProximity ligation assayes
dc.subjectPLAes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleUsefulness of identifying G-protein-coupled receptor dimers for diagnosis and therapy of neurodegenerative diseases and of gliomases
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.33, nº9 (2018)