Publication: Usefulness of identifying G-protein-coupled receptor dimers for diagnosis and therapy of neurodegenerative diseases and of gliomas
Authors
Reyes Resina, Irene ; Aguinaga, David ; Labandeira García, José Luis ; Lanciego, José Luis ; Navarro, Gemma ; Franco, Rafael
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-963
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info:eu-repo/semantics/article
Description
Abstract
y. Immunochemical detection of G-proteincoupled receptors (GPCRs) in cells and tissues was a
technical challenge for years. After the discovery of
formation of GPCR dimers/trimers/tetramers in
transfected cells, a most recent challenge has been to
confirm receptor-receptor interactions in natural sources.
The occurrence of dimers or higher order oligomers is
important from a therapeutic point of view, mainly
because their physiology/pharmacology is different from
those of individual receptors. On the one hand,
pathophysiological factors need to count more on GPCR
dimers than on individual receptors. On the other hand,
the expression of dimers, trimers, etc. may change in
pathological conditions and/or along the course of a
disease. This review will focus on G-protein-coupled
receptor dimers, on how to detect them by novel
histological techniques and on how the detection may be
used in diagnosis and therapy of ailments of the central
nervous system, for instance in neurodegenerative
diseases and gliomas.
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CB1 , CB2 , Cannabinoid receptor , GPR55 , Adenosine receptor , Dopamine receptor , D1 , D2 , D3 , Heteroreceptor complex , Proximity ligation assay , PLA
Citation
Histology and Histopathology, Vol.33, nº9, (2018)
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