Publication: Topically applied azaphenothiazines inhibit contact sensitivity to oxazolone in mice
Authors
Artym, Jolanta ; Kocięba, Maja ; Zaczyńska, Ewa ; Zimecki, Michał ; Jeleń, Małgorzata ; Morak Młodawska, Beata ; Pluta, Krystian ; Kaleta Kuratewicz, Katarzyna ; Madej, Jan P. ; Kuropka, Piotr ; Kuryszko, Jan
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-921
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info:eu-repo/semantics/article
Description
Abstract
In this work we investigated the efficacy of
two topically applied azaphenothiazine derivatives, 9-
c h l o r o - 6 - a c e t y l ami n o b u t y l q u i n o b e n z o [ 3 , 2 -
b][1,4]thiazine (compound 4) and 6-chloroethylureidoethyldiquino[3,2-b;2’;3’-e][1,4]thiazine (compound 5),
in the amelioration of inflammatory symptoms of
contact sensitivity (CS) to oxazolone in mice, in relation
to the commercial ointment Protopic® (tacrolimus), the
reference drug. The compounds were administered 24 h
following elicitation of CS and, 24 h later, the
parameters of inflammation, such as ear edema, blood
composition, leukocyte level, numbers of cells in the
draining lymph nodes, histological picture of the
inflamed tissue, and the morphometric analysis, were
analyzed. The study showed that the effectiveness of the
studied azaphenothiazines applied as a 0.1% ointment
was comparable to the reference drug regarding
suppression of the inflammatory process, when all the
investigated histological parameters are taken into
account.
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Citation
Histology and Histopathology, Vol.33, nº2, (2018)
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