Publication:
Melatonin as a mediator of the gut microbiota–host interaction: implications for health and disease

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antioxidants-13-00034-v2-1.pdf(2.1 MB)
Date
2023-12-23
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Authors
Rol de Lama, María de los Ángeles ; Bonmatí Carrión, María de los Ángeles
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Publisher
MDPI
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Fisiología
DOI
https://doi.org/10.3390/antiox13010034
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info:eu-repo/semantics/article
Description
© 2023 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in Antioxidants. To access the final edited and published work see https://doi.org/10.3390/antiox13010034
Abstract
In recent years, the role played by melatonin on the gut microbiota has gained increasingly greater attention. Additionally, the gut microbiota has been proposed as an alternative source of melatonin, suggesting that this antioxidant indoleamine could act as a sort of messenger between the gut microbiota and the host. This review analyses the available scientific literature about possible mechanisms involved in this mediating role, highlighting its antioxidant effects and influence on this interaction. In addition, we also review the available knowledge on the effects of melatonin on gut microbiota composition, as well as its ability to alleviate dysbiosis related to sleep deprivation or chronodisruptive conditions. The melatonin–gut microbiota relationship has also been discussed in terms of its role in the development of different disorders, from inflammatory or metabolic disorders to psychiatric and neurological conditions, also considering oxidative stress and the reactive oxygen species-scavenging properties of melatonin as the main factors mediating this relationship.
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Melatonin , Gut microbiota , Obesity , Sleep , Neurodegenerative disorders , Metabolism , Inflamatory bowel disease
Citation
Antioxidants, 2024, Vol. 13 (1) : 34
URI
http://hdl.handle.net/10201/154385
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