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Frequent DYRK2 gene amplification in micropapillary element of lung adenocarcinoma - an implication in progression in EGFR-mutated lung adenocarcinoma

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dc.contributor.authorKoike, Chihiro
dc.contributor.authorOkudela, Koji
dc.contributor.authorMatsumura, Mai
dc.contributor.authorMitsui, Hideaki
dc.contributor.authorSuzuki, Takehisa
dc.contributor.authorArai, Hiromasa
dc.contributor.authorKataoka, Toshiaki
dc.contributor.authorIshikawa, Yoshihiro
dc.contributor.authorUmeda, Shigeaki
dc.contributor.authorTateishi, Yoko
dc.contributor.authorOhashi, Kenichi
dc.date.accessioned2023-01-10T09:59:35Z
dc.date.available2023-01-10T09:59:35Z
dc.date.issued2021
dc.description.abstractThe present study aimed to discern the molecular alterations involved in the progression of EGFR-mutated lung adenocarcinoma (LADC). We previously demonstrated that the micropapillary (mPAP) element is the most important histological factor for assessing malignant grades in LADCs. Therefore, mPAP and other elements were separately collected from three cases of EGFR-mutated LADC using laser capture microdissection and subjected to a comprehensive mRNA expression analysis. We focused on DYRK2 in this study because its level showed a substantial increase in EGFR-mutated LADCs with mPAP. We also immunohistochemically examined 130 tumors for the expression of DYRK2. The results confirmed a strong expression of DYRK2 in EGFR-mutated LADC with mPAP. Fluorescent in situ hybridization (FISH) analyses targeting the DYRK2 locus revealed frequent gene amplification in EGFR-mutated LADC, specifically occurring in the high-grade components, like mPAP. In summary, the results of this study suggest that DYRK2 overexpression through gene amplification is one of the molecular mechanisms responsible for promoting the progression of EGFR-mutated LADC.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.doihttps://doi.org/10.14670/HH-18-294
dc.identifier.eisbnHistology and Histopathology Vol. 36, nº3 (2021)es
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/127009
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDYRK2es
dc.subjectLung adenocarcinomaes
dc.subjectEGFR mutationses
dc.subjectMicropapillaryes
dc.subjectAdenocarcinoma progressiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleFrequent DYRK2 gene amplification in micropapillary element of lung adenocarcinoma - an implication in progression in EGFR-mutated lung adenocarcinoma
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36, nº3 (2021)