Publication: Chromosomal instability and human hepatocarcinogenesis
Authors
Nishida, N. ; Nishimura, T. ; Ito, T. ; Komeda, T. ; Fukuda, Y. ; Nakao, K.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Recently, many studies have identified losses
and gains of several chromosomal loci in human
hepatocellular carcinoma (HCC) with fine microsatellite
analysis and comparative genomic hybridization.
Although distribution of aberrant chromosomal arms
differs among HCCs, loss of 1p, 4q, 6q, 8p, 9p, 10q,
13q, 16q and 17p, and gain of 1q, 6p, 8q, 17q and 20q
have been recurrently reported, and loss of 4q and 16q
seems to occur preferentially in hepatitis B virus-related
HCCs. Accumulation of these aberrant chromosomal
regions is associated with tumor progression, and some
chromosomal aberrations, such as loss of 1p, are
frequently identified in well-differentiated HCCs and
also detected even in dysplastic nodule and cirrhotic
nodule. This evidence suggests that chromosomal
instability (CIN) emerges at an early stage during
hepatocarcinogenesis and is successively inherent to
tumor cells, resulting in acquisition of malignant
phenotype. The molecular basis of CIN is beginning to
be explored; however, several mechanisms may be
involved for CIN of HCC.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.