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Lysophosphatidic acid receptors in cancer pathobiology

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dc.contributor.authorTsujiuchi, Toshifumi
dc.contributor.authorAraki, Mutsumi
dc.contributor.authorHirane, Miku
dc.contributor.authorDong, Yan
dc.contributor.authorFukushima, Nobuyuki
dc.date.accessioned2019-01-29T16:28:03Z
dc.date.available2019-01-29T16:28:03Z
dc.date.issued2014
dc.description.abstractLysophosphatidic acid (LPA) receptors (LPA1 to LPA6) are G protein-coupled transmembrane and mediate a variety of biological responses through the binding of LPA, such as cell proliferation, migration, morphogenesis and differentiation. Previously, high secretion levels of LPA were found in blood and ascites from patients with aggressive ovarian cancer. So far, numerical studies have demonstrated that LPA signaling via LPA receptors contributes to the acquisition of malignant potency by several cancer cells. Moreover, genetic and epigenetic alterations of LPA receptor genes have been detected in cancer cells. Therefore, it is suggested that LPA signaling may be a target molecule for the establishment of chemoprevention agents in clinical cancer approaches. Here, we review the current knowledge for the biological roles of LPA signaling via LPA receptors in the pathogenesis of cancer cells.es
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dc.format.extent8es
dc.identifier.citationHistology and Histopathology, vol. 29, nº 3 (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/67041
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectLPA receptores
dc.subjectCanceres
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleLysophosphatidic acid receptors in cancer pathobiologyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº 3 (2014)