Publication: Apoptosis regulating genes in neuroendocrine tumors
Authors
Liu, W.-H. ; Wang, D.-G.
item.page.secondaryauthor
item.page.director
Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Neuroendocrine turnors (NETs) are a
heterogeneous group of neoplasms. They are relatively
uncommon and characterised by a relatively indolent
clinical course. The indolent nature of NETs has long
been enigmatic and recent advances in apoptosis
research have led to speculation regarding the role of
programmed cell death in NET tumorigenesis. It is
hoped that a fundamental molecular understanding will
help explain these variant behaviors that are so evident
to the clinician, and ultimately yield novel and more
effecti ve therapies.
Recent studies have demonstrated that deregulation
of programmed cell death may be a critical component
in the multistep tumorigenesis of NETs and that the
frequent expression of the BCL-2 oncoprotein in these
tumors may contribute to their pathogenesis. The genetic
complementation of simultaneously deregulated BCL-2
and c-MYC may be implicated in the multistep
tumorigenesis of human NETs. It is also clear that
numerous cellular gene products can and will be shown
to impact upon apoptosis in NETs; some of these may
even be molecules identified as oncoproteins or tumor
suppressors. The major challenge will be to ascribe
primary pathogenetic significance to tumor-associated
derangements in expression of these molecules, and
hopefully to then exploit our knowledge toward
therapeutic benefit.
publication.page.subject
Citation
Histology and Histopathology, Vol. 15, n.º 3 (2000)
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/