Publication: Immunohistochemistry of cytokeratins 7, 8, 17, 18,
and 19, and GLUT-1 aids differentiation of desmoplastic
malignant mesothelioma from fibrous pleuritis
Authors
Horiuchi, Toshikatsu ; Ogata, Sho ; Tominaga, Susumu ; Hiroi, Sadayuki ; Kawahara, Kunimitsu ; Hebisawa, Akira ; Irei, Isao ; Ito, Ichiro ; Kameya, Toru ; Tsujimura, Tohru ; Nakano, Takashi ; Nakanish, Kuniaki ; Kawai, Toshiaki
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
It is difficult to distinguish desmoplastic
malignant mesothelioma (DMM) from fibrous pleuritis
(FP). We investigated the utility of immunohistochemistry
as a way of differentiating between DMM and
FP. We examined 11 DMMs and 46 FPs with the aid of
antibodies against 18 cytokeratin (CK) subtypes,
calponin, caldesmon, desmin, and GLUT-1. The best
sensitivity and specificity cut-off values in the receiver
operating characteristic curves (ROC) for CKs 7, 8, 17,
18, and 19, and GLUT-1 were each above 60%. When
cases with either DMM or FP were partitioned by the
staining score associated with the best sensitivity and
specificity cut-off values in ROC, the incidence of a
positive expression for CKs 7, 8, 17, 18, and 19, and
GLUT-1 was significantly higher in DMM than in FP. In
conclusion, immunohistochemistry for CKs 7, 8, 17, 18,
and 19, and GLUT-1 may be useful, alongside
histological characteristics, for separating DMM from
FP.
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Citation
Histology and histopathology, Vol. 28, n.º 5 (2013)
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