Publication: Styrene hepatotoxicity in rats treated by inhalation or intraperitoneally: a structural investigation
Authors
De Piceis Polver, P. ; Fenoglio, C. ; Nano, R. ; Coccini, T. ; Bertone, V. ; Vaccarone, R. ; Gerzeli, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The purpose of this study was to investigate
the toxicity of styrene in the liver of adult rats treated
either by inhalation of styrene vapour (300 ppm, 6 h/d, 5
d/wk, for 2 wk) or intraperitoneally with different
styrene doses (4, 40, 400 mg/Kg) for 3 consecutive days.
Using a light microscope, some alterations of liver
parenchyma and sinusoid dilation were noticed, more
marked in the group treated with the intraperitoneal
administration of the chemical. Using an electron
microscope, some additional changes were observed
(once again, more marked in the latter group of rats): a)
an increase in the content of lipids inside hepatocytes,
and b) the rise of intracytoplasmic, intercellular and
perisinusoidal collagen fibres. Therefore, cell damage
and functional disturbance of sinusoids due to
perisinusoidal fibrosis are apparent in the liver of both
groups of rats exposed to styrene treatment, but these
changes are definitely more significant in those
subjected to intraperitoneal administration.
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