Publication: Exploring the relationship of brown adipose tissue to bone microarchitecture using 7T MRI and micro-CT
Authors
Zhang, Ping ; Yu, Baohai ; Shao, Shuying ; Zhang, Ranxu ; Zeng, Yan ; Li, Jujia ; Ren, Congcong ; Zhou, Xiaoyue ; Zhao, Jian
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-481
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info:eu-repo/semantics/article
Description
Abstract
Background. Brown adipose tissue (BAT) is
involved both in energy production and bone
metabolism. The purpose of this study was to analyze
the relationship between BAT and microarchitecture at
cancellous and cortical bone using Kunming mice and
the methods of 7T magnetic resonance imaging (MRI)
combined with micro-CT.
Methods. Twenty-four female Kunming mice were
examined by 7T MRI and measured T2* relaxation time
on the deep and superficial interscapular BAT (iBAT)
and subcutaneous white adipose tissue (sWAT).
Cancellous bone microarchitecture of the distal femur
and cortical bone of the middle femur were examined by
micro-CT. A paired t-test was used to analyze the
differences in T2* values between iBAT and sWAT. The
correlation between BAT T2* values and bone
microstructure parameters were analyzed using
Pearson’s correlation.
Results. T2* values of the deep and superficial iBAT
(6.36±3.31 ms and 6.23±2.61 ms) were significantly
shorter than those of sWAT (16.30±3.05 ms, tdeep iBAT=-
10.816), tsuperficial iBAT=-12.276, p<0.01). Deep iBAT
T2* values were significantly and negatively correlated
with bone volume, cancellous thickness, and bone
thickness (Th) and trabecular thickness (Tb.Th) of the
cancellous bone of femur. Deep iBAT T2* values were
significantly and positively correlated with the structural
model index of cancellous bone of femur. Deep iBAT
T2* values were significantly and negatively correlated
with bone mineral density of the cortical bone of femur.
Conclusions. MRI can distinguish the two adipose
tissues from each other. T2* values of BAT were lower
than WAT on MRI. BAT related bone remodeling was
more correlated with the microstructure of cancellous
bone than that of cortical bone.
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Citation
Histology and Histopathology Vol. 37, nº11 (2022)
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