Publication: Spatio-temporal expression patterns of microRNAs
in remodelling and repair of the infarcted heart
Authors
Chiarella-Redfern, H.H. ; Rayner, K.J. ; Suuronen, E.J.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-30.141
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info:eu-repo/semantics/article
Description
Abstract
MicroRNAs (miRNAs) are small, nonmessenger RNAs, 20-22 nucleotides in size, which
regulate gene expression at the post-transcriptional level.
Typically, miRNAs target the 3’ untranslated region
(3'UTR) of mRNA transcripts leading to mRNA
degradation or translational repression. The known
dysregulation of miRNAs during cardiac ischemia and
the crucial role of miRNA-dependent regulation of
angiogenesis, fibrosis and hypertrophy present
interesting therapeutic opportunities for repairing and
regenerating the heart after myocardial infarction (MI).
An understanding of the expression pattern and
localization of deleterious and beneficial miRNAs
during cardiac ischemia is necessary for the
development of therapeutics designed to specifically
treat the affected tissue and cell populations. This review
focuses on the role and localization of key miRNAs
implicated in MI while highlighting how their
manipulation may promote cardiac repair.
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Citation
Histology and Histopathology, Vol. 30, n.º 2 (2015)
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