Publication: Angiogenesis and the role of bone marrow endothelial cells in haematological malignancies
Authors
De Raeve, H. ; Van Marck, E. ; Van Camp, B. ; Vanderkerken, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Increased microvessel density (MVD) has
been observed in the bone marrow (BM) of patients with
multiple myeloma (MM), acute lymphoblastic
leukaemia, acute myeloid leukaemia, and
myelodysplastic and myeloproliferative syndrome. The
MVD is the net result of cumulative phases of
angiogenesis and angio-regression and is as such not an
indicator of the ongoing angiogenesis at the time of
biopsy. There is, therefore, a need for additional methods
that allow the estimation of ongoing angiogenesis.
Double immunostainings for CD34 and Ki-67 can be
used on paraffin-embedded tissue to determine the
endothelial proliferation fraction. The BM endothelial
cells, as a component of the BM stroma, have a close
interaction with the malignant cells. In MM, for
example, they are involved in the specific homing and
are a source of paracrine growth factors. Targeting the
BM microvessels will not only influence the nutrient and
oxygen supply, but will in addition reduce the growth
stimuli provided by the EC.
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