Publication: FOXP1 status in splenic marginal zone lymphoma, a fluorescence in situ hybridization and immunohistochemistry approach
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Date
2009
Authors
Baró, Cristina ; Espinet, Blanca ; Salido, Marta ; Colomo, Lluis ; Luño, Elisa ; Florensa, Lourdes ; Ferrer, Ana ; Salar, Antonio ; Campo, Elías ; Serrano, Sergi ; Solé, Francesc
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Splenic marginal zone lymphoma (SMZL) is
a well-recognized entity in which chromosomal
aberrations seem to be potential markers in diagnosis,
prognosis and disease monitoring.
FOXP1 is a transcriptional regulator of B
lymphopoiesis that is deregulated in some types of NHL.
Translocation t(3;14)(p14;q32) has been described in
marginal zone lymphomas but few series have studied
FOXP1 involvement in SMZL. We performed
cytogenetic, fluorescence in situ hybridization (FISH)
and immunohistochemical (IHC) studies in a series of 36
patients in order to study the status of FOXP1 in this
entity.
According to our results, FOXP1 is not rearranged in
SMZL, although we were able to demonstrate gains of
FOXP1 gene due to trisomy 3/3p by FISH. FOXP1
protein expression seemed to be not related to any
aberration and IHC studies are not conclusive.
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