Publication:
The Mycobacterium marinum-zebrafish model to study host-pathogen interactions in tuberculosis

Simple item page
dc.contributor.authorRoca Soler, Francisco José
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.date.accessioned2026-02-25T16:13:23Z
dc.date.available2026-02-25T16:13:23Z
dc.date.issued2018
dc.description.abstractWhile Tumor Necrosis Factor (TNF) is host protective in mycobacterial infections, its excess is pathogenic. TNF excess triggers production of mitochondrial reactive oxygen species (ROS) that cause programmed necrosis (necroptosis) of infected macrophages through the participation of the mitochondrial protein cyclophilin D, a regulator of mitochondrial permeability transition. Here we show that mitochondrial ROS mediate necrosis through a signaling pathway that traverses the lysosome, cytosol, and endoplasmic reticulum (ER) before returning to the mitochondrion to execute cell death. We have identified the specific proteins, including Ca2+ channels, which orchestrate this pathway, which we will present. In summary, we find that mitochondrial Ca2+ overload is the ultimate feature in the pathway responsible for TNF-mediated programmed necrosis in infected macrophages. We identify currently used calcium channel blockers as well as drugs that specifically inhibit ER calcium release as pharmacological interventions that prevent pathogenic necrosis in tuberculosis.
dc.formatapplication/pdf
dc.format.extent1
dc.identifier.urihttp://hdl.handle.net/10201/213542
dc.languageeng
dc.relationSin financiación externa a la Universidad
dc.relation.ispartofInvited keynote speaker
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.odsObjetivo 3: Salud
dc.titleThe Mycobacterium marinum-zebrafish model to study host-pathogen interactions in tuberculosis
dc.typeinfo:eu-repo/semantics/conferenceObject
dspace.entity.typePublicationes
relation.isAuthorOfPublication7f46a88a-1ff4-4f80-948e-7d636b80e75d
relation.isAuthorOfPublication.latestForDiscovery7f46a88a-1ff4-4f80-948e-7d636b80e75d
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
39ESM_Dresden_FR_abstract.pdf
Size:
67.94 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.37 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Ponencias y Comunicaciones