Publication:
Adrenomedullin regulates club cell recovery following lung epithelial injury

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dc.contributor.authorGarcía-Sanmartín, Josune
dc.contributor.authorLarrayoz, Ignacio M.
dc.contributor.authorMartínez, Alfredo
dc.date.accessioned2021-07-26T10:42:47Z
dc.date.available2021-07-26T10:42:47Z
dc.date.issued2016
dc.description.abstractThe equilibrium between lung epithelium damage and recovery in the context of chronic injury is at the basis of numerous lung diseases, including lung cancer and COPD. Understanding the contribution of growth factors and other molecular intermediates to this crosstalk may help in devising new therapeutic approaches. To better understand the contribution of adrenomedullin (AM) to lung homeostasis, we built club cell-specific conditional knockout (KO) mice for AM and subjected them to naphthalene injury. Untreated KO mice had lower levels of club cell 10 KDa protein (CC10) immunoreactivity than their wild type (WT) littermates in both terminal and regular bronchioles. Naphthalene injury resulted in a rapid necrosis of club cells followed by a progressive recovery of the epithelium. Club cells proliferated at higher rates in the KO mice and at 21 days post-injury the club cell coverage of the main bronchioles was higher and more homogeneous than in the WT animals. In conclusion, the paracrine/autocrine influence of AM in club cells subtly modulates their proliferation and spreading kinetics during lung epithelium recovery.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.doiDOI: 10.14670/HH-11-704
dc.identifier.eisbnHistology and histopathology: Vol.31, nº6 (2016)es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/111343
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAdrenomedullines
dc.subjectClub cellses
dc.subjectNaphthalenees
dc.subjectLung injuryes
dc.subjectBrdUes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleAdrenomedullin regulates club cell recovery following lung epithelial injuryes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.31, nº6 (2016)