Publication: Human papillomavirus (HPV)-induced neoplasia in the urinary bladder: a missing link?
Authors
Alexander, Riley E. ; Wang, Lisha ; Lopez-Beltran, Antonio ; Emerson, Robert E. ; Montironi, Rodolfo ; Pedrosa, Jose A. ; Kaimakliotis, Hristos Z. ; Koch, Michael O. ; Cheng, Liang
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-11-715
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info:eu-repo/semantics/article
Description
Abstract
The discovery that the role human
papillomavirus (HPV) plays in the induction of human
cancer represents an important achievement in oncologic
research. It has taken on even greater importance since
the development of vaccines, which promise the hope of
preventing these cancers from ever occurring. Because
of these important implications, many have attempted to
determine a possible role for the virus in cancers of the
urinary bladder-an organ in close anatomic proximity to
the primary sites of HPV-induced neoplasia and one
which already has an established oncogenic infectious
agent in Schistosoma haematobium. Here we review the
current literature exploring this possible role in the most
common subtype of cancer of the urinary bladder,
urothelial carcinoma, and two much more rare histologic
subtypes that have well established roles for HPVinduced neoplasia in other anatomic sites-squamous cell
carcinoma and adenocarcinoma.
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Citation
Histology and histopathology: Vol.31, nÂş6 (2016)
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