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A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity

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dc.contributor.authorCuenca, Lorena
dc.contributor.authorPizzichini, Elisa
dc.contributor.authorGonçalves, Valeria C.
dc.contributor.authorGuillén Díaz, María
dc.contributor.authorAguilar Moñino, Elena
dc.contributor.authorSánchez Rodrigo, Consuelo
dc.contributor.authorGonzález Cuello, Ana María
dc.contributor.authorFernández Villalba, Emiliano
dc.contributor.authorHerrero, María Trinidad
dc.contributor.departmentEnfermería
dc.date.accessioned2024-02-09T09:23:08Z
dc.date.available2024-02-09T09:23:08Z
dc.date.created2021-04
dc.description©2021. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Published version of a Published Work that appeared in final form in International Journal of Molecular Sciences. To access the final edited and published work see https://doi.org/ 10.3390/ijms22094341
dc.description.abstractThe diurnal rodent Octodon degus (O. degus) is considered an attractive natural model for Alzheimer’s disease and other human age-related features. However, it has not been explored so far if the O. degus could be used as a model to study Parkinson’s disease. To test this idea, 10 adult male O. degus were divided into control group and MPTP-intoxicated animals. Motor condition and cognition were examined. Dopaminergic degeneration was studied in the ventral mesencephalon and in the striatum. Neuroinflammation was also evaluated in the ventral mesencephalon, in the striatum and in the dorsal hippocampus. MPTP animals showed significant alterations in motor activity and in visuospatial memory. Postmortem analysis revealed a significant decrease in the number of dopaminergic neurons in the ventral mesencephalon of MPTP animals, although no differences were found in their striatal terminals. We observed a significant increase in neuroinflammatory responses in the mesencephalon, in the striatum and in the hippocampus of MPTP-intoxicated animals. Additionally, changes in the subcellular expression of the calcium-binding protein S100 were found in the astrocytes in the nigrostriatal pathway. These findings prove for the first time that O. degus are sensitive to MPTP intoxication and, therefore, is a suitable model for experimental Parkinsonism in the context of aging.es
dc.formatapplication/pdfes
dc.format.extent19es
dc.identifier.doihttps://doi.org/ 10.3390/ijms22094341
dc.identifier.issnPrint: 1661-6596
dc.identifier.issnElectronic: 1422-0067
dc.identifier.urihttp://hdl.handle.net/10201/139068
dc.languageenges
dc.publisherMDPIes
dc.relationThis research was supported by Fundación Séneca (19540/PI/14) and by Spanish Ministry of Science and Innovation (FIS PI13/01293). LCB is granted by the Spanish Ministry of Science, Innovation and Universities (FPU 18/02549). EP by the “Torno Subito”, Programme promoted by the Regione Lazio and managed by DiSCo Lazio (1912116092019). VCG is granted by CAPES (88882330550/2019-01) and receives a CAPES-Print scholarship (88887469009/2019-00).es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAgeinges
dc.subjectParkinson’s diseasees
dc.subjectNeurodegenerationes
dc.titleA New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidityes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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