Publication: True S-cones are concentrated in the ventral mouse retina and wired for color detection in the upper visual field
Authors
Francisco M. Nadal-Nicolás ; Vincent P. Kunze ; John M. Ball ; Brian T. Peng ; Akshay Krishnan ; Gaohui Zhou ; Lijin Dong ; Wei Li
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Facultades de la UMU::Facultad de Medicina
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Publisher
eLife Sciences Publications, Ltd.
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DOI
doi: 10.7554/eLife.56840.
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info:eu-repo/semantics/article
Description
Abstract
Color, an important visual cue for survival, is encoded by comparing signals from photoreceptors with different spectral sensitivities. The mouse retina expresses a short wavelength-sensitive and a middle/long wavelength-sensitive opsin (S- and M-opsin), forming opposing, overlapping gradients along the dorsal-ventral axis. Here, we analyzed the distribution of all cone types across the entire retina for two commonly used mouse strains. We found, unexpectedly, that ‘true S-cones’ (S-opsin only) are highly concentrated (up to 30% of cones) in ventral retina. Moreover, S-cone bipolar cells (SCBCs) are also skewed towards ventral retina, with wiring patterns matching the distribution of true S-cones. In addition, true S-cones in the ventral retina form clusters, which may augment synaptic input to SCBCs. Such a unique true S-cone and SCBC connecting pattern forms a basis for mouse color vision, likely reflecting evolutionary adaptation to enhance color coding for the upper visual field suitable for mice’s habitat and behavior.
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Citation
Elife. 2020 May 28;9:e56840.
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