Publication: Nothobranchius as a model for aging studies. A review
Authors
Lucas-Sánchez, Alejandro ; Almaida Pagán, Pedro Francisco ; Mendiola, Pilar ; Costa, Jorge de
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Publisher
ISOAD
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DOI
https://doi.org/10.14336/AD.2014.0500281
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info:eu-repo/semantics/article
Description
This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published version of a Published Work that appeared in final form in Aging and Disease. To access the final edited and published work see
https://doi.org/10.14336/AD.2014.0500281
This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published version of a Published Work that appeared in final form in Aging and Disease. To access the final edited and published work see https://doi.org/10.14336/AD.2014.0500281
This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published version of a Published Work that appeared in final form in Aging and Disease. To access the final edited and published work see https://doi.org/10.14336/AD.2014.0500281
Abstract
In recent decades, the increase in human longevity has made it increasingly important to expand our knowledge on aging. To accomplish this, the use of animal models is essential, with the most common being mouse (phylogenetically similar to humans, and a model with a long life expectancy) and Caenorhabditis elegans (an invertebrate with a short life span, but quite removed from us in evolutionary terms). However, some sort of model is needed to bridge the differences between those mentioned above, achieving a balance between phylogenetic distance and life span. Fish of the genus Nothobranchius were suggested 10 years ago as a possible alternative for the study of the aging process. In the meantime, numerous studies have been conducted at different levels: behavioral (including the study of the rest-activity rhythm), populational, histochemical, biochemical and genetic, among others, with very positive results. This review compiles what we know about Nothobranchius to date, and examines its future prospects as a true alternative to the classic models for studies on aging.
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Citation
Aging and Disease, Vol 5, Number 4; 281-291
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