Publication:
Immunomodulation by collagen VI across fibrotic and tumor microenvironmental contexts

Simple item page
dc.contributor.authorSharon Gerecht
dc.contributor.authorJennifer H. Hammel
dc.contributor.departmentBiología Celular e Histología
dc.contributor.editorUniversidad de Murcia, Departamento de Biologia Celular e Histiologia
dc.date.accessioned2026-07-02T07:49:25Z
dc.date.available2026-07-02T07:49:25Z
dc.date.issued2026
dc.description.abstractThe extracellular matrix (ECM) plays fundamental roles in modulating tissue structure and function under normal and pathological conditions. ECM composition is an essential consideration for studying cellular microenvironments, as varied composition leads to changes in cell behavior and delivery of therapeutics. Collagen VI is a non-fibrillar collagen that is found in both fibrotic and tumor microenvironments, where it promotes disease progression and suppresses the immune system. In this review, we summarize the contributions of collagen VI to fibrosis and tumor progression, followed by a focus on its ability to modulate the immune system in these contexts. Finally, we explore whether collagen VI could be a suitable therapeutic target for future study. While many studies have demonstrated the importance of collagen VI in disease progression, further studies of its immunomodulation abilities are needed to fully realize its potential as a therapeutic target in fibrosis and the tumor microenvironment.
dc.formatapplication/pdf
dc.format.extent16
dc.identifier.doihttps://doi.org/10.14670/HH-25-034
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/240981
dc.languageeng
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCollagen VI
dc.subjectFibrosis
dc.subjectTumor microenvironment
dc.subjectExtracellular matrix
dc.subjectImmunomodulation
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleImmunomodulation by collagen VI across fibrotic and tumor microenvironmental contexts
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Hammel-41-1153-1168-2026.pdf
Size:
7.66 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.37 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology, Vol.41, Nº 7, (2026)