Publication: Immunomodulation by collagen VI across fibrotic and tumor microenvironmental contexts
Authors
Sharon Gerecht ; Jennifer H. Hammel
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Publisher
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Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-25-034
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info:eu-repo/semantics/article
Description
Abstract
The extracellular matrix (ECM) plays
fundamental roles in modulating tissue structure and
function under normal and pathological conditions.
ECM composition is an essential consideration for
studying cellular microenvironments, as varied
composition leads to changes in cell behavior and
delivery of therapeutics. Collagen VI is a non-fibrillar
collagen that is found in both fibrotic and tumor
microenvironments, where it promotes disease
progression and suppresses the immune system. In this
review, we summarize the contributions of collagen VI
to fibrosis and tumor progression, followed by a focus
on its ability to modulate the immune system in these
contexts. Finally, we explore whether collagen VI could
be a suitable therapeutic target for future study. While
many studies have demonstrated the importance of
collagen VI in disease progression, further studies of its
immunomodulation abilities are needed to fully realize
its potential as a therapeutic target in fibrosis and the
tumor microenvironment.
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Citation
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Este Ãtem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/